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Updated: Jan 13, 2026

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卢克索利提尼布抑制了口服角质细胞中因干扰素-γ 诱导的 JAK/STAT 激活

Kim N Stolte1, Anna Fedorova1, Sameh Attia1

  • 1Department of Periodontology, Oral Medicine and Oral Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Berlin, Germany.

Clinical and experimental dental research
|January 10, 2026
PubMed
概括

简氏激酶 (JAK) /信号转换器和转录激活器 (STAT) 途径是口腔炎症的关键. 卢克索利提尼布有效地抑制了干扰素 (IFN-γ) 诱导的STAT1激活和HLA-DRB1表达在口腔角质细胞中,表明了治疗潜力.

关键词:
雅努斯酶抑制剂的使用亚努斯基纳酶是亚努斯基纳酶的一种.干扰素 - 玛干扰素类平坦的类.通过口腔的口腔口腔.

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