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Updated: Jul 21, 2026

Step-specific Sorting of Mouse Spermatids by Flow Cytometry
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在小鼠中,对西斯丁诱导的精子生成缺陷的蛋白质组分析

Pengyu Li1,2, Ziran Chen2, Zexuan Zhang2

  • 1Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Key Laboratory for Pathogenesis and Immunodiagnosis of Rheumatic and Immunological Diseases, Hohhot, China.

Annals of medicine
|January 10, 2026
PubMed
概括

西斯普拉丁化疗通过减少精子数和影响生殖细胞来损害男性生育能力. 这项研究表明,青降低了循环林依赖性激酶1 (CDK1) 的表达,这是精子生成的关键调节者,导致生殖功能障碍.

关键词:
在CDK1中,CDK1是指CDK1.精子发生是精子生成.西斯普拉丁 (cisplatin) 是一种制剂.造成精子受损的伤害.

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相关概念视频

Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...