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功能性肺避开放射治疗用于肺癌的应用和进展

Shuqing Yang¹, Jun Xu², Yulong Yang³

¹Department of Oncology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.

Journal of medical imaging and radiation oncology

|January 10, 2026

概括

功能性肺成像 (FLI) 识别功能性肺 (FL) 区域,以指导功能性肺回避放射治疗 (FLART). FLART精确地降低辐射剂量,以避免肺损伤,改善患者的生活质量.

科学领域:

在瘤学瘤学.
医疗成像医学成像
辐射疗法辐射疗法

背景情况:

肺癌的放射治疗 (RT) 可以导致辐射诱导的肺损伤 (RILI),影响患者的生活质量 (QOL) 和生存率.
传统的RT假定肺功能均,可能会过度暴露健康的肺组织.
肺功能异质性需要先进的成像技术来进行个性化治疗.

研究的目的:

审查功能性肺成像 (FLI) 模式及其在缓解RILI方面的作用.
探索功能性肺回避放射治疗 (FLART) 的概念和临床应用.
讨论FLART对患者QOL的影响,并确定当前的局限性.

主要方法:

对FLI技术 (SPECT,PET,MRI,CT) 的现有文献的审查.
对肺 perfusion (Q) 作为 RILI 的替代标记物的分析.
检查FLART原则和临床实施策略.

主要成果:

肺 perfusion 影像 FLI,特别是肺 perfusion 影像,提供了一种评估功能性肺 (FL) 区域的方法.
FLART利用FLI数据来定制辐射剂量分配,以节省功能性肺.
在减少RILI发病率和改善肺癌患者的QOL方面,FLART显示出希望.

结论:

在RT规划中,FLI对于理解肺功能异质性至关重要.
在减少RILI和提高患者的治疗结果方面,FLART代表了重大进展.
需要进一步的研究来优化FLART技术并解决现有的局限性.

关键词:

肺功能测试肺功能测试肺功能测试肺部瘤是什么肺部瘤辐射剂量辐射剂量辐射性肺炎的发生辐射疗法辐射疗法

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