在修改自然循环辅助生殖技术中卵细胞检索的成功:一项回顾性队列研究
Yonghuan Lv1,2, Shan Wu3, Miao Miao1,2
1Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.
概括
临床因素不会影响在修改后的自然循环中卵细胞的检索. 然而,在注射人类胆性淋巴激素 (HCG) 之前,激素水平升高可能会增加在生育治疗期间成功检索卵细胞的可能性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 卵细胞检索是辅助生殖技术 (ART) 中的一个关键步骤.
- 了解影响卵细胞检索成功的因素对于优化生育治疗至关重要.
- 修改后的自然循环为传统的ART协议提供了替代方案.
研究的目的:
- 调查临床因素和荷尔蒙特征对在修改后的自然周期中的卵细胞检索的影响.
- 在接受体外受精 (IVF) /细胞内精子注射 (ICSI) 的女性中,确定成功卵细胞检索的预测因素.
主要方法:
- 从2018年至2023年间,对306名接受了试管婴儿/ICSI的妇女的数据进行了回顾性分析.
- 评估临床参数,荷尔蒙水平 (孕激素,雌激素,LH,AMH,FSH,,甲状腺) 和卵泡发育.
- 具有和没有成功的卵细胞检索的组之间的比较.
主要成果:
- 在基线临床因素 (年龄,BMI,不孕不育类型/持续时间,医疗状况) 中,检索和非检索组之间没有发现显著差异.
- 在取回组中,在注射人类胆激素 (HCG) 之前和之后,发现了显著更高水平的孕激素,雌激素和黄素化激素 (LH).
- 抗穆勒尔激素 (AMH) 水平在各组之间有显著差异,而FSH,和甲状腺激素水平则没有.
结论:
- 临床因素似乎没有影响在修改后的自然循环ART.卵细胞检索率.
- 在HCG服用当天,激素水平升高,特别是雌激素和孕激素,可能与成功取卵细胞的更高概率有关.
- 这些发现可能有助于完善修改自然循环治疗的协议.
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