早期更年期和与代谢功能障碍相关的肥胖性肝病风险:全球队列研究
Joshua Stokar1,2, Rivka Dresner-Pollak1,2
1Department of Endocrinology, Hadassah Medical Center, Jerusalem, Israel.
Diabetes/metabolism research and reviews
|January 10, 2026
概括
在50岁之前经历更年期的女性面临患代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险更高. 这一发现强调了在妇女健康评估中考虑更年期时间的重要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个重要的健康问题,特别关注肝脏和心血管并发症.
- 在50岁左右的女性中,MASLD的患病率急剧上升,但早期更年期和MASLD风险之间的联系仍然不清楚.
研究的目的:
- 调查自然更年期较早的年龄与患MASLD的风险之间的联系.
- 检查早期更年期和与MASLD相关的关键代谢因素之间的关系.
主要方法:
- 使用TriNetX网络进行的一项回顾性队列研究确定了50岁前更年期的女性.
- 倾向性得分匹配被用来创建可比的队列,不包括过早/手术更年期的病例,脂肪性肝病的其他原因或激素治疗.
- 结果包括在5年的随访期内对MASLD和相关代谢条件的新诊断.
主要成果:
- 较早的更年期 (<50岁) 与患MASLD (HR 1.322) 的风险增加显著相关.
- 更年期较早的女性也表现出新发性脱脂血症 (HR 1.083) 和糖尿病前期 (HR 1.130) 的风险增加.
- 这些关联在通过先前存在的代谢风险因素分层的分析中保持一致.
结论:
- 50岁前更年期与MASLD的风险增加有关.
- 将更年期时间纳入女性特异性心脏代谢风险评估中需要进一步调查.
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