在NIH-AARP队列研究中,刺激性肠综合征与所有原因和特定原因死亡率之间的时间依赖关系
Daniela S Gutiérrez-Torres1, Fangyu Li1,2, Linda M Liao1
1Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
The American journal of gastroenterology
|January 10, 2026
概括
患有刺激性肠综合征 (IBS) 的人,全因死亡风险较低,随着时间的推移,死亡率下降. 这种IBS和死亡率之间的反向关联需要进一步调查促成因素.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于刺激性肠综合征 (IBS) 与死亡率之间的关联,存在相互矛盾的证据.
- 这项研究旨在澄清IBS和死亡率在大型队列中的关系.
研究的目的:
- 估计IBS与所有原因和特定原因死亡率之间的关联.
- 调查这种关联在延长后续期内如何变化.
主要方法:
- 使用的医疗保险索赔数据用于IBS诊断 (1994-2008) 和国家死亡指数用于死亡结果 (到2019年).
- 采用多变量Cox比例危险回归模型来分析死亡风险.
- 调整为包括饮食和医疗保健访问代理程序在内的混因素.
主要成果:
- 在132,697人中,3.8%的人被确诊患有常见的IBS诊断.
- 最初,IBS与2-5年内所有原因死亡率 (HR=0.75) 的风险降低25%有关.
- 这种反向关联随着时间的推移而减弱,超过17年后的风险降低了8% (HR=0.92).
- 还观察到癌症和心血管疾病死亡率的风险较低,随着时间的推移而减弱.
结论:
- 在IBS和全因,癌症和心血管疾病死亡率之间发现了时间依赖的反向关联.
- 获得医疗保健和个人健康倡导似乎混了短期的关联.
- 需要进一步的研究,以了解在更长的随访期间影响这些关联的因素.
相关概念视频
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