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Updated: Jan 13, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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一个迈凯利斯-阿尔布佐夫型通路到一个受保护的2'-脱氧-2'-二甲基-腺-3',5'-酸基酸氨酸二核酸,用于修改的m7G Cap合成

K Lawrence E Hale1, Helen O McCarthy2, Mark G McLaughlin1

  • 1School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, Northern Ireland, UK.

Chemistry (Weinheim an der Bergstrasse, Germany)
|January 10, 2026
PubMed
概括

这项研究详细介绍了一种新型甲基化二核酸的合成,这是潜在的mRNA疗法的关键组成部分. 这种分子对于未来创建m7G cap 1结构至关重要.

关键词:
5′-O-酸化的方法迈凯利斯-阿尔布佐夫的氨酸酸盐结合法.周围的三酸盐效应m7G的帽子上限可以使用.没有→ σ* P-O 过度结合.核酸O2′-triflate的排位方式核酸烯甲基化核酸.在固体CPR II中使用.这是酸盐α效应.

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