晚期前列腺癌的雄激素导向治疗的长期趋势:29年国家分析
Kieran Sandhu1, Cynthia Wells2, Matilda M H Newton3,4
1Division of Cancer Services, Peter MacCallum Cancer Centre, Parkville, Australia. kieran.s11@outlook.com.
International urology and nephrology
|January 10, 2026
概括
澳大利亚已经从化激素释放激素 (LHRH) 激素激剂转向雄激素受体通路抑制剂 (ARPI) 用于晚期前列腺癌治疗. 这一转变凸显了卫生系统结构对采用新型高价值疗法的影响.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 雄激素剥夺疗法 (ADT) 是晚期前列腺癌 (PCa) 管理的基石.
- 雄激素受体通路抑制剂 (ARPI) 已经彻底改变了PCa治疗范式.
- 在现实世界中,ARPI的采用模式需要全面的描述.
研究的目的:
- 在29年的时间里,研究澳大利亚的雄激素导向疗法的处方趋势.
- 描述晚期前列腺癌治疗选择的时间演变.
- 评估ARPI引入对处方模式的影响.
主要方法:
- 药品福利计划 (PBS) 的回顾性分析,从1996年至2024年发布数据.
- 包括素激素释放激素 (LHRH) 激动剂,联合雄激素阻断 (CAB) 和ARPI.
- 标准化每10万男性每年处方数量和中断时间序列 (ITS) 分析.
主要成果:
- 总的抗雄激素处方显著增加,从146增加到228,707 (1996-2024年).
- 单一治疗的LHRH从>94%下降到51.61%,而ARPI从2.44%上升到47.28% (2013-2024).
- ITS分析证实,在ARPI引入后,ARPI使用量显著增加.
结论:
- 澳大利亚已经转向广泛使用ARPI,从主要基于LHRH的疗法转向广泛使用ARPI.
- 促进及时获取的卫生系统结构对于高价值疗法的传播至关重要.
- 这项研究强调了晚期前列腺癌治疗在现实世界实践中的动态转变.
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