记录环境中获得的Mycobacterium intracellulare亚种. 在支气管切开症发作后不久的奇梅拉肺病
Jennifer R Honda1, Rachel N Wilsey1, Chelsea K Raulerson1
1Department of Cellular and Molecular Biology, School of Medicine, University of Texas Health Science Center at Tyler, Tyler, TX, 75708 USA.
概括
确定支气管切除症患者如何感染非结核性真菌菌 (NTM) 仍然具有挑战性. 这项研究将家庭暴露与气管支气管病发后的NTM疾病发展联系起来,该研究得到了热点地区环境采样的支持.
科学领域:
- 环境微生物学环境微生物学
- 肺部医学 肺部医学
- 传染病流行病学 传染病流行病学
背景情况:
- 支气管切开症是一种慢性肺部疾病,其特征是不可逆转的气道扩张.
- 非结核性真菌菌 (NTM) 是环境病原体,可以引起肺部感染,特别是在有支气管病等潜在肺部疾病的个体中.
- 在支气管切除症患者中,NTM获取的精确来源和时间尚不清楚.
研究的目的:
- 调查长期家庭环境暴露与患有支气管切除症的患者中NTM肺病的发展之间的潜在联系.
- 为了将NTM肺部疾病的发病与已知的NTM地理热点内的纵向环境采样数据相关联.
主要方法:
- 案例研究方法侧重于单个房主患有支气管切除症.
- 在患者的家庭内长时间进行纵向环境采样.
- 环境NTM检测和NTM肺病的临床进展之间的相关性分析.
主要成果:
- 数据表明,家庭长时间暴露于环境和NTM肺部疾病的发展之间存在潜在的关联.
- 患者中NTM疾病的发病与环境采样中的特定发现相关.
- 该研究是在一个被公认为NTM地理热点地区的地区进行的,提供了相关的环境背景.
结论:
- 本案例研究提供了初步证据,支持这样一个假设:长期家庭环境暴露可能会导致 bronchiectasis 患者获得 NTM.
- 需要对更大的队列进行进一步的研究,以证实这些发现,并阐明NTM在这种患者群体中传播的机制.
- 了解环境暴露途径对于开发针对性预防策略对于支气管切除症患者的NTM感染至关重要.
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