在精神分裂症中由长期作用的帕利皮里顿棕酸诱导的长期晚期运动障碍症:一个病例报告
Yu-Ming Chen1, Shangwen Chang1,2
1Department of Psychiatry, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
The American journal of case reports
|January 10, 2026
概括
一种运动障碍 - - 晚期 dystonia,在长期服用帕利皮里棕酸盐抗精神病药物治疗后可能会出现. 虽然可能会延长,但这种阳性综合征可能会通过管理策略显示部分改善.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 迟性动力障碍 (TD) 是一种具有异常非自愿运动特征的阳性综合征,通常与因多巴胺受体对抗性而导致的抗精神病药物有关.
- 本病例报告的重点是一个40岁的精神分裂症妇女,在长期使用帕利皮里棕酸盐治疗后经历了持续的TD.
研究的目的:
- 用于描述长效注射帕利皮里暴露后持续的晚期 dystonia 的病例.
- 讨论这种阳性运动障碍的长期管理和潜在的可逆性.
主要方法:
- 一份病例报告,详细说明精神分裂症和晚期动症患者的临床表现,治疗过程和诊断过程.
- 在6年的时间里,对患者对各种药理干预措施的反应进行了审查,包括停止帕利佩里,阿里皮普拉,辅助药物,克洛扎宾和弗卢沃胺.
主要成果:
- 患者在长期暴露于帕利皮里3个月后出现了持续的宫姿势和面具状面部,被诊断为晚期 dystonia.
- 尽管停止了帕利佩里和包括VMAT-2抑制剂在内的各种治疗辅助药物,但在6年内, dystonia 仅呈现逐渐的,不完全的改善.
结论:
- 晚期 dystonia 可能是长期作用的注射性 paliperidone 的长期并发症,表现出部分可逆性.
- 临床医生应保持对TD的高度怀疑,尽量减少多巴胺受体阻断暴露,并考虑包括VMAT-2抑制剂或克洛扎宾在内的个性化管理,以及运动监测.
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