对毒性及其治疗策略的概述
Pushkar Singh Rawat1, Shalini Singh2
1Department of Biochemistry, University of Lucknow, Lucknow, Uttar Pradesh 226007, India.
概括
毒性是一个全球性的健康问题,特别是在发展中国家. 食补充剂提供了一种具有成本效益和安全的策略,以减轻中毒及其严重的健康影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- (Pb) 是一种普遍存在的有毒重金属,广泛用于工业,导致全球污染升级.
- 的毒性对公共健康构成重大威胁,特别是在发展中国家,经常呈现无症状的重叠症状.
- 诊断依赖于血液Pb水平 (BLLs) 和查血液学变化,包括红细胞分解和氨酸水平变化.
研究的目的:
- 在多个器官系统中审查 (Pb) 的全身毒性.
- 调查与Pb暴露相关的基因毒性影响和癌症风险.
- 探索食补充剂和先进的化疗法作为Pb毒性的管理策略.
主要方法:
- 关于毒性的综合文献审查.
- 对Pb对呼吸,血液,神经,心血管,肝脏,脏,骨和生殖系统的影响分析.
- 检查基因毒性,癌症风险和治疗干预措施,包括食补充剂和化剂.
主要成果:
- 暴露会影响多个器官系统,导致全身毒性,基因毒性和潜在的癌症风险.
- 食补充剂 (植物化学品,维生素,益生菌等) 显示出对Pb毒性的保护作用.
- 化疗法 (CaNa2EDTA,DMPS,化剂等) 是一种治疗方法. 是高级管理选项.
结论:
- 食补充剂是一种简单,经济有效和安全的方法来降低Pb的毒性.
- 与其他治疗方法相比,营养策略提供了显著的好处,副作用较少.
- 综合管理包括补充剂和化是对抗Pb毒性至关重要的.
更多相关视频
08:46Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
Published on: April 21, 2022
2.7K
08:35Extending the Lifespan of Soluble Lead Flow Batteries with a Sodium Acetate Additive
Published on: January 7, 2019
9.6K
相关概念视频
01:26Toxic Reactions: Overview
1.8K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.8K
01:26Drug Discovery: Overview
10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
01:27Effects of Chemicals: Overview
1.9K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.9K
01:17Antidotes
1.0K
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
1.0K
01:26Anticholinesterase Agents: Poisoning and Treatment
1.5K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.5K
01:14Prevention of Further Absorption of Poison
1.2K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.2K