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马尔迪质谱图像显示了海洋的氧诱导的代谢异质性

Ruiyue Wang¹, Yijiao Qu¹, Jiameng Sun¹

¹Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical, Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100190, China.

Journal of hazardous materials

|January 10, 2026

概括

防晒中的一种成分氧化,通过积聚在它们的组织中并破坏新陈代谢,特别是在紫外线下,对海造成伤害. 这项研究揭示了其空间分布和代谢效应,突出了氧化应激作为关键损伤因素.

科学领域:

海洋生物学海洋生物学
环境毒理学环境毒理学
代谢学代谢学代谢学

背景情况:

防晒中的氧化与珊瑚漂白有关.
之前的研究已经确定了氧化在珊瑚和海中的毒性机制.
氧在海中的空间分布和代谢影响仍然不太清楚.

研究的目的:

在不同的紫外线条件下,研究氧对海的影响.
绘制 oxybenzone 的空间分布及其对内源代谢产物的影响.
为了阐明紫外线辐射在氧化毒性中的作用.

主要方法:

使用了矩阵辅助激光消耗/电离质谱成像 (MALDI-MSI).
绘制了氧和代谢产物的空间分布图.
分析了不同度的氧松与无紫外线照射的影响.

主要成果:

氧化在海的海柱上优先积聚于触手上.
紫外线辐射显著增强了氧化的毒性.
观察到分区代谢失调,特别是在谷氨酸代谢和TCA循环中间体中.
氧化应激被确定为损伤的主要原因.

结论:

紫外线辐射对于激活海中的氧松毒性至关重要.
空间代谢学揭示了海组织中的局部代谢干扰.
研究结果提供了关于氧和个人护理产品在海洋生物中的空间毒理学的见解.

关键词:

矩阵辅助激光脱/离子化质谱成像 (MALDI-MSI) 技术氧基松是一种氧化.个人护理产品 (PCP)海是一种海.空间代谢学空间代谢学

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