在多发性硬化症中双耳听力,神经障碍和脑成像
Gary Rance1, Julien Zanin1, Daniel Merlo2
1The University of Melbourne, Department of Audiology and Speech Pathology, Carlton, Victoria, Australia.
Multiple sclerosis and related disorders
|January 10, 2026
概括
听力问题在多发性硬化症 (MS) 患者中很常见,影响声音检测和语音理解. 这些听力缺陷源于中枢神经系统的脱髓化,而不仅仅是外周听力损失,影响生活质量.
科学领域:
- 神经科学是一个神经科学.
- 听力学 听力学是指听力学.
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 是一种炎症性自身免疫性疾病,导致中枢神经系统中髓的破坏.
- 听力缺陷是常见的,但在MS患者中经常被诊断不足.
- 脱素可以破坏中央听觉通路,影响听力能力.
研究的目的:
- 检查复发性复发性MS患者的声音检测值和功能性听力.
- 评估外周和中央听觉功能,包括语音感知和空间听觉.
- 为了将听力缺陷与神经障碍和MS中的大脑变化相关联.
主要方法:
- 30名多发性硬化患者和30名匹配对照人接受了听力测试,双耳语音感知测试,空间听力测试 (在空间化噪音中听力) 和自我报告的听力障碍问卷.
- 评估了神经障碍,白质病变数量/体积和整个大脑体积.
- 分析了听觉测量和神经/大脑指标之间的相关性.
主要成果:
- 18/30多发性硬化症患者的声音检测水平异常.
- 多发性硬化症患者表现出明显较差的双耳语音感知,特别是在声音定位任务中 (P<.001).
- 较差的语音感知与较大的神经障碍和较低的大脑体积相关;较差的双耳处理与增加的病变和较低的大脑体积相关.
结论:
- 多样性硬化症患者的听力缺陷与中枢神经系统脱和神经退行有关,而不仅仅是外周听力损失.
- 在MS患者中,中央听觉处理和语音感知显著受损.
- 临床医生应在MS患者中查外周和中央听力缺陷,因为它们会影响生活质量.
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