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在多发性硬化症 (CoVaR-MS) 中的真实世界COVID-19免疫力:一项纵向随访研究

Seema Kalra¹, David Jenkinson², Sarah Goddard³

¹Neurology Department, University Hospitals of North Midlands NHS Trust, Newcastle Road, Stoke-on-Trent, Staffordshire, ST4 6QG, UK; Keele School of Medicine, University of Keele, Staffordshire, ST5 5BG, UK.

Multiple sclerosis and related disorders

|January 10, 2026

概括

多发性硬化症 (MS) 患者的COVID-19疫苗接种提供了持续的免疫力,尽管一些疾病修饰疗法 (DMT) 影响抗体水平. 推使用增强剂,特别是对于服用Ocrelizumab和Fingolimod的人.

科学领域:

免疫学免疫学免疫学
神经学神经学
疫苗学疫苗学疫苗学

背景情况:

接受疾病修饰治疗 (DMT) 的多发性硬化症 (MS) 患者对COVID-19免疫评估提出了独特的挑战.
免疫抑制的变化需要在这个人群中对疫苗有效性的真实数据.

研究的目的:

评估与健康志愿者 (HV) 相比,MS (PwMS) 患者在COVID-19疫苗接种后持久的血清和细胞免疫力.
为了分析特定的DMT对COVID-19免疫力随时间推移的影响.

主要方法:

一项纵向实验性研究,涉及205个PwMS (涉及各种DMT,包括Alemtuzumab,Dimethyl fumarate,Fingolimod,Interferon,Natalizumab,Ocrelizumab或没有DMT) 和30个HV.
在<=18和<=24个月的疫苗接种后进行的血清和细胞免疫测定.
统计分析以比较群体之间的免疫水平和不良事件发生率.

主要成果:

在PwMS和HV中观察到高免疫率 (97%在<=18个月,96.9%在<=24个月).
接受Ocrelizumab的PwMS显示血清免疫力降低,但保持细胞免疫力;Fingolimod显著降低了这两种免疫力.
其他DMT组对HV表现出相似的免疫力;所有组的不良事件率都相似.

结论:

在大多数PwMS中,COVID-19疫苗接种会引起持久免疫力,但像Fingolimod和Ocrelizumab这样的DMT可以调节免疫反应.
数据支持PwMS对COVID-19疫苗增剂的建议,特别是对Ocrelizumab和Fingolimod的建议.
了解DMT特异性免疫反应对于优化MS患者疫苗接种策略至关重要.

关键词:

抗SARS-CoV-2 /N IgG抗体罗氏公司这是COVID-19疫苗.COVID-19,免疫力免疫力免疫力免疫力疾病改变治疗方法.多发性硬化症是多发性硬化症.这就是SARS-CoV-2病毒.在T-SPOT® COVID中使用T-SPOT®

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