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基于的金属有机框架增强了高强度聚焦超声波的术后免疫疗法

Xinchang Huang¹, Xirui Luo¹, Tong Su²

¹Department of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016 Chongqing, PR China; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, 400016 Chongqing, PR China.

Journal of colloid and interface science

|January 10, 2026

概括

新的AMSMOF通过同时提供药物和STING激动剂来增强高强度聚焦超声波 (HIFU) 治疗. 这种组合可以增强抗瘤免疫力,并抑制手术后癌症复发.

科学领域:

生物医学工程生物医学工程
癌症免疫疗法癌症免疫疗法
材料科学材料科学材料科学

背景情况:

高强度聚焦超声波 (HIFU) 疗法由于抗原呈现不足和免疫反应较弱,其疗效有限.
术后瘤复发和转移仍然是癌症治疗的重大挑战.

研究的目的:

设计基于的金属有机框架 (AMS MOFs),用于联合输送banoxantrone (AQ4N) 和SR-717.
为了增强HIFU手术后与抗原呈现相关的免疫治疗.
为了改善接受HIFU手术的患者的预后.

主要方法:

合成的AMSMOFs同时提供了AQ4N (低氧激活前药物) 和SR-717 (STING激动剂).
在HIFU手术后的低氧微环境中评估了联合疗法.
评估了免疫反应,包括I型干扰素信号传递和抗原呈现.

主要成果:

AQ4N诱导免疫细胞死亡,并释放与危险相关的分子模式.
SR-717激活了由Mn2+增强的STING通路.
协同效应促进了抗原呈现和I型干扰素反应,抑制了瘤复发和转移.

结论:

开发的AMS MOFs战略有效地增强了HIFU触发的免疫疗法.
这种方法有望改善各种手术的术后结果,包括HIFU.
同时提供AQ4N和SR-717代表了一种可行的策略,用于打击瘤复发.

关键词:

抗原交叉呈现抗原交叉呈现乳腺癌是什么? 乳腺癌是什么这就是HIFU.免疫治疗是一种免疫疗法.MOFs 的使用情况.

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