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可通过脏清除的有机NIR-II染料集群用于非侵入性尿路成像

Shengjie Ma¹, Zimu Yuan², Chenlong Yu²

¹Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130012, PR China; Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun, 130021, PR China; Changbaishan Laboratory, Jilin University, Changchun, 130000, PR China.

|January 10, 2026

概括

一个新的近红外II (NIR-II) 光探测器,IR-FEP1000,在结直肠癌手术期间提供非侵入性,高分辨率的尿路可视化. 这一进步有助于预防手术损伤,并指导精确的瘤切除.

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
有机化学有机化学

背景情况:

在结直肠癌 (CRC) 手术中,手术内尿管可视化非常重要,但目前的侵入性方法限制了这一点.
现有技术的光稳定性较差,空间分辨率不足,对重要器官构成风险.
第二次近红外 (NIR-II) 光成像提供了一种具有增强组织透和分辨率的非侵入性替代方案.

研究的目的:

开发和评估一种新的NIR-II光探针,用于CRC手术期间实时,高分辨率的尿路可视化.
评估探针在检测尿管损伤和指导复杂的外科手术过程中的性能.
探索复合NIR-II成像的潜力,同时可视化瘤和关键的解剖结构.

主要方法:

通过单工艺合成基于捐赠者-接受者-捐赠者的NIR-II探针 (IR-FEP1000集群).
探测器的光学特性,光稳定性和脏分泌途径的表征.
在体内评估尿路成像性能和在模拟手术场景中的应用,包括多重成像.

主要成果:

IR-FEP1000集群显示出出色的光漂白抵抗性,高分辨率和延长的成像窗口.
该探针在静脉注射和代谢后实现了卓越的非侵入性尿路成像.
多复合NIR-II成像成功可视化了CRC转移,尿道和肠道,促进了精确的手术指导.

结论:

在复杂的手术环境中,IR-FEP1000集群是用于非侵入性,高分辨率和长时间尿路成像的有希望的工具.
这项技术通过使精确的瘤切除,同时保护重要器官,提高了手术安全性.
多复合的NIR-II成像代表了在瘤外科手术中的手术内指导的重大进步.

关键词:

结肠直肠癌是一种癌症.DAD型的小分子.在NIR-II光成像技术中使用NIR-II光成像技术.手术导航手术导航手术导航尿道成像尿道成像

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