使用MPA封顶的AgInS2量子点同时确定阿莫西西林和克拉夫兰酸:一种基于光的化学测量方法
Rafael C Castro1, Ricardo N M J Páscoa1, João L M Santos1
1LAQV, REQUIMTE, Department of Chemical Sciences, Laboratory of Applied Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
|January 10, 2026
概括
一种使用AgInS2量子点的新光谱测量方法提供了一种简单,快速和具有成本效益的方法,可以同时确定药品中的阿莫西林 (AMX) 和克拉夫兰酸 (CLA),取代有毒溶剂.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 药品分析 药品分析
背景情况:
- 同时确定阿莫西西林 (AMX) 和克拉夫兰酸 (CLA) 对于制药质量控制至关重要.
- 现有的方法可能是复杂的,耗时的,或依赖于危险的溶剂.
- 需要简单,快速,具有成本效益和可靠的分析技术.
研究的目的:
- 开发一种用于同时确定AMX和CLA的新型光谱计量方法.
- 为了利用AgInS2量子点 (QDs) 用酸 (MPA) 作为光探针.
- 为了将QD光与化学测量相结合,用于多重检测.
主要方法:
- 合成和评估各种AgInS2 QDs以获得最佳的灵敏度.
- 应用一个完整的因数实验设计,以进行可靠的分析.
- 使用展开的部分最小平方 (U-PLS) 建模动力光数据.
- 通过分析不同的光谱区域,优化U-PLS模型.
主要成果:
- 开发的方法实现了高准确性,预测的相对误差 (REP) 为AMX的2%和CLA的11%.
- 整个光谱区域为U-PLS建模提供了最好的结果.
- 与官方USP染色法相比,没有观察到统计学上显著的差异.
结论:
- 这种新型的光谱计量方法是精确,可靠和具有成本效益的.
- 它为AMX和CLA分析提供了传统色谱方法的有价值的替代方案.
- 该方法消除了对有毒溶剂的需求,促进了更绿色的分析实践.
相关概念视频
Precipitation Titration: Endpoint Detection Methods
In argentometric precipitation titrations, endpoints can be detected visually by the Mohr, Volhard, and Fajans methods. In the Mohr method, adding a soluble chromate indicator gives an initial yellow color to the analyte solution. As the titrant is added, the first excess of silver ions forms a red silver chromate precipitate, marking the endpoint. The solution pH should be maintained at about 8 by adding solid CaCO3.
In the Volhard method, a standard excess of AgNO3 is first added to the...
In the Volhard method, a standard excess of AgNO3 is first added to the...
Atomic Absorption Spectroscopy: Lab
For AAS measurements, samples must be introduced as clear solutions, often requiring extensive preliminary treatment to dissolve materials like soils, animal tissues, and minerals. Common methods for sample preparation include treatment with hot mineral acids, wet ashing, combustion in closed containers, high-temperature ashing, or fusion with reagents.
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing nebulizer...
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing nebulizer...
Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation
Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used.
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used.
Atomic Emission Spectroscopy: Lab
AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
Atomic Fluorescence Spectroscopy
Atomic fluorescence spectroscopy (AFS) is an analytical technique that involves the electronic transitions of atoms in a flame, furnace, or plasma being excited by electromagnetic (EM) radiation. When these atoms absorb energy, they become excited and subsequently release energy as they return to their original state. This emitted light, or "fluorescence," is observed at a right angle to the incident beam. Both absorption and emission processes transpire at distinct wavelengths, which are...


