戴蒙德在鼻癌:是时候放弃西斯了吗?
Emma R Y Zhang1, Ya Juan Zhou2, Melvin L K Chua3
1Division of Medical Sciences, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583, Singapore; Department of Mathematics, University of California, Los Angeles, 520 Portola Plaza, MS 6363, Los Angeles, CA 90095-1555, USA.
Med (New York, N.Y.)
|January 10, 2026
概括
第三阶段的DIAMOND试验发现,在接受抗PD-1治疗的晚期鼻癌患者中,无锡的治疗方案与含锡的治疗方案的生存率相似. 这种方法还减少了副作用,改善了生活质量.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 免疫治疗是一种免疫疗法.
背景情况:
- 区域性先进的鼻癌 (LA-NPC) 传统上涉及并发的西斯-放射治疗.
- 反编程死亡-1 (anti-PD-1) 疗法已成为LA-NPC治疗的关键组成部分.
- 齐斯普拉丁与放射治疗和抗PD-1疗法的结合作用需要进一步研究.
研究的目的:
- 在LA-NPC患者中,与含有西斯的治疗方案相比,评估无西斯治疗方案的疗效和安全性.
- 在两个治疗臂中评估无故障生存率 (FFS).
- 为了比较与治疗相关的不良事件的发生率,特别是吐,以及它们对生活质量的影响.
主要方法:
- 第三阶段的DIAMOND试验招募了LA-NPC.患者.
- 参与者接受了诱导,并发和辅助抗PD-1疗法.
- 患者被随机分配到含有思普拉丁或无思普拉丁的治疗方案以及放射治疗.
主要成果:
- 在含有思柏和无思柏的手臂之间观察到可比的3年无故障生存率.
- 无锡的治疗方案导致了与锡相关的吐的显著减少.
- 在接受无锡普拉丁治疗方案的患者中报告了改善的生活质量.
结论:
- 无锡的方法是用抗PD-1疗法治疗的LA-NPC中传统的含锡的疗法的一个可行的替代方案.
- 省略西斯不影响生存结果,并提供减少毒性和改善生活质量的好处.
- 这些发现挑战了在LA-NPC管理中同时使用西斯与放射治疗的既定做法.
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