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Updated: Jan 13, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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一只老鼠的昼夜蛋白质组图谱

Yuta Otobe1, Norie Deki-Arima2, Shao Xinyan3

  • 1Circadian Clock Project, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa 2-1-6, Setagaya-ku, Tokyo 156-8506, Japan.

Molecular cell
|January 10, 2026
PubMed
概括

科学家们通过分析32种组织,创建了一个全面的小鼠昼夜蛋白质组图谱. 该资源揭示了跨时空的蛋白质表达模式,有助于研究日常生物节奏.

关键词:
昼夜时钟是生物周期的时间表.昼夜节律 昼夜节律质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量核定位的核定位酸化的方法是:光化.蛋白质组分析 蛋白质组分析

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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