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产后抑郁症中的宿主-肠道微生物代谢交叉:一个多体的洞察力,将血液代谢物与表观遗传调节联系起来

Zhiyuan Zhang¹, Xiaobing Hu¹, Weimin Tao¹

¹Department of Anesthesiology and Critical Care, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 201204, China.

Journal of affective disorders

|January 10, 2026

概括

这项研究将肠道细菌如Clostridia和Bifidobacteriales与产后抑郁症 (PPD) 风险联系起来. 主体代谢基因由DNA甲基化和代谢物调节,在PPD的肠-大脑-代谢物轴中发挥关键作用.

科学领域:

遗传学是一个遗传学.
微生物学微生物学
代谢学代谢学代谢学
神经科学是一个神经科学.

背景情况:

新出现的证据表明肠道微生物群,其代谢物和产后抑郁症 (PPD) 之间存在联系.
这些相互作用对宿主新陈代谢的确切影响需要进一步阐明.

研究的目的:

调查肠道微生物群组成和PPD风险之间的因果关系.
确定关键的宿主代谢基因和参与PPD的调节机制.
探索宿主-代谢物-微生物群相互作用在PPD病变发生过程中的作用.

主要方法:

利用两样本的孟德尔随机化 (MR) 与全基因组关联研究 (GWAS) 的肠道微生物群和PPD的数据.
采用两步式MR来识别潜在的血液代谢物和基于eQTL和mQTL的总结数据的MR (SMR) 来确定因果基因.
通过便微生物QTL (mbQTL) 进行了局部化分析,以检查基因-微生物群相互作用.

主要成果:

确定了特定的肠道细菌 (例如,Clostridia,Bifidobacteriales,Eggerthella,Prevotella) 与PPD风险积极相关,而Verrucomicrobia显示有保护作用.
揭示了高密度脂蛋白 (HDL) 作为关键的中间代谢物,将Bifidobacteriales与PPD联系起来.
确定了七个血液代谢基因 (例如RAF1,GATM,SLC3A1) 和与PPD相关的调节性DNA甲基化位点,其中FDXR,RAF1,GATM和SLC3A1参与了基因-微生物群相互作用.

结论:

参与PPD的宿主代谢基因受到DNA甲基化和代谢物介导的与肠道微生物群的相互作用的影响.
这些发现为开发针对肠-大脑-代谢物轴的基于机制的策略提供了基础,用于预防和治疗PPD.

关键词:

我们的肠道微生物群.整合性奥米克学科门德尔的随机化代谢过程中的代谢.产后抑郁症产后抑郁症

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