高剂量维生素D补充剂在怀孕期间改变了小鼠的组织特异性维生素D代谢物分布
Iskander L C Shadid1, Henk-Jan Guchelaar2, Bruce D Levy3
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, the Netherlands.
The Journal of nutrition
|January 10, 2026
概括
怀孕改变了维生素D代谢物分布,肺部积累了25-氧维生素D (25[OH]D). 在妊娠期间高剂量补充显示出对胎儿25[OH]D积累的潜在保护机制.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 怀孕显著影响维生素D的新陈代谢,影响母亲和胎儿的健康.
- 维生素D代谢物在胎盘功能和胎儿发育中的作用至关重要,但尚未完全理解.
- 在怀孕期间补充维生素D代谢物的局部组织度在很大程度上是未知的.
研究的目的:
- 在补充维生素D后量化25-氧维生素D (25[OH]D) 和1,25-二氧维生素D (1,25[OH]2D) 的组织度.
- 研究孕期如何改变这些维生素D代谢物在母体和胎儿组织中的分布.
- 在小鼠模型中评估怀孕期间高剂量维生素D补充剂的安全性和耐受性.
主要方法:
- 小鼠接受了正常或高剂量的维生素D3补充剂四周.
- 建立了怀孕和非怀孕的对照组.
- 血清,肺,肝脏,脏,胎盘和胎儿组织在妊娠日18.5.5收集.
- 使用LC-MS/MS测量维生素D代谢物度.
主要成果:
- 高剂量的维生素D以剂量依赖的方式增加了血清25(OH) D水平.
- 怀孕导致血清1,25(OH) 2D的增加和组织分布的改变,肺部显示高25(OH) D积累.
- 尽管有胎盘积累,但高剂量组的胎儿25(OH) D是较低的,这表明了和机制.
- 在怀孕期间,高剂量补充剂被很好地容忍.
结论:
- 怀孕诱导维生素D代谢物的显著再分配,涉及脏和胎盘.
- 产前维生素D补充剂会影响这种分布.
- 超生理性母体维生素D剂量可能会降低胎儿的25(OH) D摄入量,这可能表明存在保护机制.
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
7.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.5K
01:25Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K