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Updated: Jul 9, 2026

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伤害与环境的相互作用:mTBI的微质原始化通过HMGB1-RAGE轴对随后的压力产生脆弱性

Jing Qiu1, Guang Yang2, Jingling Cai3

  • 1Department of Neurosurgery, General Hospital of Central Theater Command of Chinese People's Liberation Army, Wuhan 430070 Hubei, China; Department of Geriatrics, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430074 Hubei, China; Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan 430074 Hubei, China; Hubei Provincial Institute of Traditional Chinese Medicine, Wuhan 430074 Hubei, China; Hubei Key Laboratory of theory and application research of liver and kidney in traditional Chinese medicine, Wuhan 430060 Hubei, China; Hubei Sizhen Laboratory, Wuhan 430060 Hubei, China.

Brain, behavior, and immunity
|January 10, 2026
PubMed
概括

轻度创伤性脑损伤 (mTBI) 启动大脑,使其易受压力影响. HMGB1-RAGE通路放大了这种情况,导致抑郁和神经炎症.

关键词:
慢性压力是一种慢性压力.抑郁症 抑郁症 抑郁症在HMGB1-RAGE轴上微质原始化的初始化轻微的创伤性脑损伤是轻微的神经炎症是一种神经炎症.第二次击中第二次击中.

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