在COVID后呼吸障碍中描述三个功能障碍的呼吸模式
Ivan Guerreiro1, Aurélien Bringard2, Pascal Weber3
1Division of Pneumology, Geneva University Hospitals, Geneva, Switzerland.
Respiratory physiology & neurobiology
|January 10, 2026
概括
后COVID-19综合征的功能障碍呼吸 (DB) 可以通过分析心肺运动测试 (CPET) 期间的呼吸参数,将其分为三个模式:高通风,不稳定的呼吸和平坦化. 这种分类有助于诊断和管理DB亚型.
科学领域:
- 肺部医学 肺部医学
- 心血管呼吸系统生理学
背景情况:
- 功能障碍呼吸 (DB) 呈现出呼吸和全身症状,往往导致COVID-19后综合征 (PCS) 中呼吸障碍.
- 目前的诊断挑战源于缺乏DB亚型的标准化分类.
- 心肺运动测试 (CPET) 显示了分析PCS患者呼吸模式的潜力.
研究的目的:
- 调查CPET在将DB分类为不同的模式中的实用性.
- 为了识别与不同DB亚型相关的特定通风参数变化.
主要方法:
- 对79名COVID-19后持续性呼吸道症状患者的CPET进行分析.
- 根据CPET期间的异常呼吸模式,将患者分为三个DB模式:高通风 (HYPV),不规则的呼吸 (ERBR) 和平坦化 (FLAT).
主要成果:
- 模式之间没有年龄,BMI,性别或峰值氧气吸收 (V̇O2) 的显著差异.
- 与正常 (N) 相比,HYPV和FLAT显示出较高的V̇E-V̇CO2斜率.
- FLAT和ERBR表现出较低的VT/V̇E斜率;FLAT还具有更高的峰值呼吸频率. ERBR和FLAT与症状得分升高有关.
结论:
- 在增量运动期间的呼吸参数演变有效地将DB分为HYPV,ERBR和FLAT模式.
- 这种分类方法提供了一种标准化的方法来诊断和管理PCS中的DB.
- 来自CPET的呼吸模式分析是了解和解决DB的宝贵工具.
相关概念视频
Alterations in Respiration II
1.6K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.6K
Respiratory Volumes and Capacities I
1.6K
Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
1.6K
Physical Assessment of the Respiratory Tract II: Inspection
826
Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration...
Chest Configuration
The chest configuration...
826
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K
Acute Respiratory Failure-III
756
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
756
Acute Respiratory Failure-IV
499
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
499


