与纤维素相关的血代谢物和对凝血,炎症和血管疾病的影响
Jayna C Nicholas1, Taryn Alkis2, Joshua C Bis3
1Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Journal of thrombosis and haemostasis : JTH
|January 10, 2026
概括
这项研究确定了与纤维素水平相关的270种代谢物,揭示了脂质,激素和生活方式因素之间的联系. 这些发现为凝血,炎症和血管风险提供了新的见解.
科学领域:
- 生物化学 生物化学
- 代谢学 代谢学 代谢学
- 血管生物学 血管生物学
背景情况:
- 纤维素素是一种关键的凝血因子,在血栓形成中至关重要.
- 纤维素素水平升高与慢性炎症有关.
- 纤维素原作为前凝血剂风险的定量标志物.
研究的目的:
- 为了确定与纤维素原水平相关的血代谢物.
- 探索纤维素和各种生物通路之间的关系.
- 了解与炎症,生活方式和血管风险的潜在联系.
主要方法:
- 在六个不同的美国队列 (n=10,533) 中利用非向的血代谢概况.
- 评估了789个代谢物和血纤维素原体之间的横截面关联.
- 调整了包括年龄,性别,BMI和脂蛋白水平在内的共同变量.
主要成果:
- 确定了270种与纤维素水平显著相关的代谢物 (FDR <0.05).
- 与脂类物种 (甘油脂,脂,脂肪酸) 发现的普遍关联,可能反映炎症.
- 与血清素,甲状腺素,性激素衍生物,外源性化合物和微生物共同代谢物的关联表明内源性和生活方式的影响.
结论:
- 发现了与纤维素原相关的新型代谢物生物标志物.
- 这些生物标志物可能会影响凝血和炎症通路.
- 这些发现有助于了解血管风险背后的途径.
相关概念视频
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
01:16Clot Retraction and Fibrinolysis
8.3K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.3K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
11.9K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
11.9K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
529
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
529
01:09Coagulation
9.6K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.6K
01:31Lipid-derived Compounds in the Human Body
6.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.2K