与夜班工作相关的心血管生物标志物和肠道微生物组的变化:来自中国平台工人研究的见解
Tenglong Yan1, Li Rong2, Siyuan Wang3
1School of Public Health, Lanzhou University, Lanzhou 730000, China.
Environmental research
|January 10, 2026
概括
乘车司机的夜班工作与更高的心血管风险生物标志物和改变的肠道微生物组有关. 这些发现表明,在非标准轮班工人中,肠道健康和心血管损伤之间存在联系.
科学领域:
- 职业健康 职业健康 职业健康
- 心血管科学 心血管科学
- 微生物组研究 微生物组研究
背景情况:
- 吉格经济的扩张增加了平台工人,通常有非标准的时间表,如夜班.
- 众所周知,夜班工作会扰乱昼夜节律,并增加心血管风险.
- 对平台工人的早期心血管生物标志物和肠道微生物群的具体影响尚不清楚.
研究的目的:
- 调查夜班工作与心血管生物标志物之间的关联.
- 探索夜班工作与肠道微生物组组成之间的关系.
- 为了检查夜班工作,心血管生物标志物和乘车司机肠道微生物组之间的相互作用.
主要方法:
- 一项横截面研究比较了66个夜班和175个日班在北京的叫车司机.
- 通过血液检查评估心血管生物标志物 (hs-cTnI,ET-1,NT-pro-BNP,FABP-3).
- 使用便样本的16S rDNA测序进行肠道微生物组概况,并进行生物信息学和统计分析.
主要成果:
- 夜班驾驶员的NT-pro-BNP水平显著更高,即使在对共变量进行调整后.
- 确定了20种不同丰富的肠道微生物种群,其中4种与hs-cTnI.I.相关.
- 没有发现显著的调解效应,但相关性表明肠道微生物变化与心血管风险之间存在联系.
结论:
- 乘车司机的夜班工作与不良的心血管生物标志物概况有关.
- 在夜班司机中观察到明显的肠道微生物组变化.
- 研究结果表明,肠道微生物群与夜班相关的心血管损伤之间存在潜在联系.
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