来自Aneoctochilus xingrenensis的多糖的结构特征和抗风湿性关节炎作用
Yuxin Hou1, Hongrui Wang1, Xuhui He1
1Department of Chinese Medicine Authentication, Faculty of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
International journal of biological macromolecules
|January 10, 2026
概括
来自Aneoectochilus xingrenensis的一种新型多糖,X21,显示出显著的抗风湿性关节炎 (RA) 作用. 它调节肠道微生物群和巨细胞两极分化,表明它有可能作为治疗剂和 RA 治疗的益生菌.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 微生物组学 微生物组学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特点是关节炎症和破坏.
- 传统上,Anoectochilus物种被用于医疗目的,但它们的RA活性化合物在很大程度上仍未被探索.
- 来自Anoectochilus xingrenensis (AXP) 的原始多糖在初步研究中显示出抗关节炎的特性.
研究的目的:
- 为了研究从Anoectochilus xingrenensis.的纯化多糖 (X21) 的化学结构和抗风湿性关节炎 (RA) 作用.
- 探索X21治疗作用的潜在机制,包括它对肠道微生物群和免疫细胞两极分化的影响.
- 评估X21作为一种潜在的候选药物和RA治疗的益生菌.
主要方法:
- 使用染色体技术和分子量测定,从AXP中净化和表征多糖化物X21.
- 评估X21在原诱导性关节炎 (CIA) 鼠标模型中的疗效,评估关节炎得分,体重,骨损伤和促炎细胞因子.
- 16S rRNA测序以分析肠道微生物群组成的变化,以应对X21治疗.
- 在体外和体内对巨细胞极化 (M1/M2) 和相关信号通路 (NF-κB,MAPK,JAK/STAT) 的研究.
主要成果:
- 一种分子量为2.71×104 Da的异质甘X21被分离和鉴定特征.
- 在CIA大鼠中,X21显著缓解了RA症状,降低了关节炎得分,骨损伤和促炎因素.
- 通过改变特定细菌的丰富性和增加短链脂肪酸,X21治疗恢复了肠道微生物群平衡.
- 通过调节关键信号通路,X21抑制了M1巨细胞的两极化,并促进了M2两极化.
结论:
- 来自Anoectochilus xingrenensis的X21在老鼠模型中表现出显著的抗关节炎作用.
- 通过调节肠道微生物群的组成和功能,X21充当潜在的益生菌.
- X21影响巨细胞的两极分化,为RA提供了一种新的治疗策略.
- X21代表了开发新治疗类风湿性关节炎的有希望的候选人.
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