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Updated: Aug 7, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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综合计算模拟和功能测试解码了致病性SIRT6变体中的全性失调

Haiyue Tang1, Jianyang Ao2, Guoyou Zhang3

  • 1Shanghai Key Laboratory of Flexible Medical Robotics, Institute of Medical Robotics, Artificial Intelligence Clinical Research Center for Drug Discovery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China; Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200025, China.

International journal of biological macromolecules
|January 10, 2026
PubMed
概括

在SIRT6蛋白中的结直肠癌突变 (L197P) 破坏了其结构的稳定,减少了其DNA修复和瘤抑制活性. 这项研究揭示了癌症中SIRT6功能受损背后的结构机制.

关键词:
所有的法规都是单一的.社区网络分析 社区网络分析马尔科夫状态模型分子动力学模拟的模拟.在SIRT6上.

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