与代谢功能障碍相关的脂肪性肝病是否会影响眼球循环?
Nihat Aydın1, Mustafa Capraz2, Burcu Akman3
1Department of Ophthalmology, Amasya University, Sabuncuoğlu Şerefeddin Training and Research Hospital, Amasya, Turkey.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与减少胆道厚度和改变眼动脉和大脑动脉的血流有关. 这些血管变化表明,MASLD患者的眼睛疾病风险增加.
科学领域:
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 眼睛和脑血管健康越来越被认为是系统代谢状态的指标.
研究的目的:
- 在MASLD患者中,调查眼 (中枢视网膜动脉[CRA],眼动脉[OA]) 和大脑动脉 (内心动脉[ICA],常见大脑动脉[CCA]) 的胸腔厚度 (CT) 和血液动力学参数.
- 为了评估与MASLD严重程度相关的动脉内膜介质厚度 (CIMT).
主要方法:
- 一项前性研究涉及98名MASLD患者和30名健康对照.
- 通过使用肝脏超声波测试,对MASLD患者进行了分期.
- 测量了眼睛和动脉血管参数 (CT,动脉速度,指数) 和CIMT.
主要成果:
- 与对照组相比,MASLD患者,特别是晚期患者,CT显著减少.
- 在OA,ICA和CCA中,血液动力学参数在晚期MASLD阶段显示出显著的变化 (流速降低,阻力指数增加).
- 与对照组相比,3期MASLD患者的CIMT显著升高.
结论:
- MASLD显著影响眼部血管结构,包括胆道厚度.
- 观察到的血管变化表明,MASLD可能与患眼病的风险增加有关.
- 这些发现强调了监测MASLD患者血管健康的重要性.
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