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Updated: Jan 13, 2026

A Method to Study de novo Formation of Chromatin Domains
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A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

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通过直接调节酶复合体二分化,EPOP将PRC2.1的向性限制在染色质上

Lihu Gong1,2,3,4, Xiuli Liu1,2,3, Xin Yang1,2,3

  • 1Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature communications
|January 10, 2026
PubMed
概括

EPOP蛋白质通过破坏其二聚体形成,削弱染色体结合,抑制多抑制复合体2.1 (PRC2.1). 这种调节对于在早期细胞分化过程中维持表观遗传程序至关重要.

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