在第一发精神分裂症和与临床症状和认知功能相关联的异常血氧化应激标志物
Fei Jiang1, Tingting Jin2, Qun Yang1
1Department of Psychiatry, Nantong Mental Health Center, The Fourth People's Hospital of Nantong, Nantong, PR China.
Schizophrenia (Heidelberg, Germany)
|January 10, 2026
概括
第一次精神分裂症患者表现出氧化应激失衡,具有与症状严重程度和认知缺陷相关的特定标记. 这些氧化应激变化可能提供早期精神分裂症生物标志物和治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 精神病学是一个精神病学.
背景情况:
- 氧化应激 (OS) 与精神分裂症 (SCZ) 的发展和进展有关.
- 在早期,以前没有服用过药物的SCZ患者中,特定的OS概况及其临床相关性尚未完全理解.
研究的目的:
- 为了研究第一次发作,以前没有服用过药物的SCZ患者的OS变化.
- 检查OS标志物与SCZ中的临床/认知特征之间的关联.
主要方法:
- 招募了98名第一期SCZ患者和96名健康对照.
- 测量了血中总抗氧化能力 (TAC),马隆地 (MDA),脂质过氧化 (LPO),NADPH氧化酶 (NOX),谷氨S转移酶 (GST) 和谷氨减少酶 (GR) 的水平.
- 通过正负综合征量表 (PANSS) 评估临床症状,通过神经心理状态评估可重复电池 (RBANS) 评估认知功能.
主要成果:
- 与对照组相比,SCZ患者的TAC,MDA和LPO都较高,NOX也较低.
- 在SCZ患者中观察到认知障碍,RBANS得分较低.
- GST与PANSS分数正相关,GR与负症状相关,LPO与认知功能相关 (认知,注意力,延迟回忆).
结论:
- 第一次SCZ患者表现出氧化和抗氧化系统的不平衡.
- 特定的OS标记与SCZ的症状严重程度和认知功能障碍有关.
- OS的变化可以作为潜在的早期生物标志物和精神分裂症的治疗点.
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