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Updated: Jan 13, 2026

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
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SHOC2-KRAS-PP1C复合体的结构揭示了RAS异型特异性决定因素,以及对RAS抑制剂针对复合体组合的洞察力

Daniel A Bonsor1, Lorenzo I Finci1, Jacob R Potter1

  • 1NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Nature communications
|January 10, 2026
PubMed
概括

这项研究揭示了正规RAS蛋白如何与SHOC2-PP1C形成较弱的复合体,影响癌症. 针对正规RAS (SKP) 和MRAS (SMP) 综合体提供了一种克服RAS驱动癌症耐药性的策略.

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