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培养阴性早产婴儿的抗生素暴露:为期10年的单中心研究
Cheryl Anne Mackay1,2, Elizabeth A Nathan3, Michelle Claire Porter4
1Neonatology, Child and Adolescent Health Service, King Edward Memorial Hospital, Subiaco, WA, Australia. cherylanne.mackay@uwa.edu.au.
Pediatric research
|January 10, 2026
概括
在没有败血症的早产婴儿中,长时间暴露于抗生素是常见的,并且与死亡率和发病率的增加有关. 需要制定战略来减少抗生素的使用,并改善婴儿的结果.
科学领域:
- 新生儿医学 新生儿医学
- 儿科药理学 儿科药理学
- 传染病流行病学 传染病流行病学
背景情况:
- 在新生儿重症监护室 (NICU) 中,抗生素的使用很普遍.
- 非常早产的婴儿 (<32周怀孕) 特别容易受到与抗生素相关的疾病影响.
- 了解抗生素暴露时间对培养负婴儿结果的影响至关重要.
研究的目的:
- 描述非常早产婴儿的抗生素利用模式.
- 为了研究抗生素暴露时间和新生儿结果在血培养阴性婴儿之间的关联.
主要方法:
- 婴儿<32周妊娠期 (2012-2022) 的回顾性队列研究.
- 用治疗时间 (DOT) 和抗生素利用率 (AUR) 量化抗生素暴露.
- 评估的结果包括死亡率,晚发性败血症 (LOS),死性肠球炎 (NEC),慢性肺病 (CLD),早产严重视网膜病变 (ROP) 和严重脑损伤.
主要成果:
- 分析了3235名培养阴性婴儿;26%的婴儿接受了≥5天的抗生素.
- 在研究期间,抗生素利用率 (AUR) 和治疗时间 (DOT) 减少.
- 长时间暴露于抗生素与增加的死亡率,脑损伤,NEC,ROP,LOS和CLD显著相关.
结论:
- 长时间暴露于抗生素是常见的培养负的,非常早产的婴儿.
- 虽然对培养阳性败血症至关重要,但抗生素可以伤害培养阴性婴儿.
- 这些发现需要制定战略,以减少抗生素暴露,并改善这一脆弱人群的治疗结果.
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