肠道微生物特征和循环代谢与儿童功能性便秘有关
Xiaolin Ye1, Tianzhuo Zhang1, Jin Zhou1
1Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Pediatric research
|January 10, 2026
概括
儿科功能性便秘 (FC) 与肠道微生物组的变化和改变的胆酸代谢有关. 针对这些干扰可能会为儿童便秘提供新的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物组失调与便秘有关.
- 肠道微生物群及其代谢相互作用在儿科功能性便秘 (FC) 中的特定作用尚未完全理解.
研究的目的:
- 调查患有FC的儿童的肠道微生物群变化和代谢途径变化.
- 探索肠道微生物群,胆酸代谢和儿科患者功能性便秘之间的关系.
主要方法:
- 招募了40名患有FC的儿童和40名健康对照.
- 利用16S rRNA和元基因组测序用于肠道微生物群分析.
- 进行了向代谢组测序,以分析血清代谢物水平.
主要成果:
- 患有FC的儿童表现出肠道微生物群多样性降低,巴克特罗伊德和普雷沃特拉增加,乳酸菌和双菌减少.
- 代谢分析显示了FC和对照组之间的胆酸 (BA) 代谢物,如牛和糖二氧化醇酸的差异.
- 变化的代谢物水平与特定的细菌丰度和肠道功能障碍相关.
结论:
- 儿科FC与明显的肠道微生物群变化和失调的胆酸代谢有关.
- 这些发现表明,受损的BA代谢有助于儿童的功能性便秘机制.
- 调节肠道微生物组和BA代谢为FC管理提供了潜在的治疗策略.
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