第一次分娩时的母亲晚年和长期的内分泌疾病发病风险
Odeya Rotem1, Naama Steiner1, Eyal Sheiner1
1Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Archives of gynecology and obstetrics
|January 10, 2026
概括
在较晚的孕妇年龄分娩会增加长期内分泌疾病的风险,如糖尿病和超脂血症. 35岁及以上的女性应考虑长期健康监测.
科学领域:
- 生殖健康 生殖健康
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,晚年孕产妇 (AMA) 的发生率正在上升.
- 关于在AMA分娩的母亲的长期健康后果的研究有限.
- AMA通常被定义为在第一次分娩时35岁或以上.
研究的目的:
- 调查第一个分娩时的晚年母亲年龄与内分泌疾病的长期风险之间的联系.
- 确定AMA和内分泌健康结果之间是否存在剂量反应关系.
- 确定特定的内分泌疾病,这些疾病可能在晚年第一次分娩的女性中更为普遍.
主要方法:
- 对1991年至2021年间分娩的妇女进行了以人口为基础的回顾性研究.
- 根据第一次分娩时的年龄分类的参与者:30,30-35,35-40,和>40岁.
- 排除患有先前内分泌疾病的妇女;使用卡普兰-梅尔曲线和考克斯比例危险模型进行分析,并对混因素进行调整.
主要成果:
- 总共分析了77746名女性.
- 第一次分娩时的晚年母亲年龄与糖尿病和高脂血症的长期风险增加有显著联系.
- 观察到与年龄相关的内分泌发病率明显进展,40岁以后分娩的女性风险最高.
结论:
- 第一次分娩时的晚年母亲年龄是长期内分泌疾病,特别是糖尿病和超脂血症的独立风险因素.
- 观察到的分级关联凸显了长期健康监测和预防策略对于在较晚的孕妇年龄中首次分娩的妇女的重要性.
- 进一步的研究可能会探索具体的干预措施来减轻这些风险.
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