儿童生长激素缺乏症中的生长激素治疗和眼部生物识别:系统性审查和元分析
Pedro Lucas Machado Magalhães1, Dillan Cunha Amaral2, Anderson Matheus Pereira da Silva3
1Faculty of Medicine, Institute of Medical Education, Angra dos Reis, RJ, Brazil. pedrolucas.magalhaes@icloud.com.
Eye (London, England)
|January 10, 2026
概括
在患有GH缺乏症的儿童中,生长激素 (GH) 治疗显著改变了眼部生物识别参数,包括增加眼内压力和角膜厚度,以及减小轴长. 建议对这些患者进行常规的眼睛监测.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 增长激素 (GH) 和类似胰岛素的增长因子1 (IGF-1) 对体内生长至关重要,并可能影响眼部发育.
- 对于儿童眼部生物识别参数,GH缺乏及其治疗对眼部生物识别参数的具体影响尚不清楚.
研究的目的:
- 系统地审查和分析GH缺乏和GH替代疗法对儿科患者眼部结果的影响.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane) 进行了全面的文献搜索,截至2025年1月.
- 包括的研究包括随机对照试验,队列研究和病例对照研究,比较GH治疗个体与对照个体的眼睛参数.
- 八项观察性研究符合聚合分析的纳入标准.
主要成果:
- GH疗法与眼内压升高 (平均差异[MD]1.95 mmHg) 和中枢角膜厚度 (MD 22.62 μm) 显著相关.
- GH疗法还导致球体等价值显著增加 (MD 0.45二光) 和轴长度减少 (MD -0.94毫米).
- 两组之间没有观察到折射的显著差异;中等到高的异质性被注意到,但通过灵敏度分析得到改善.
结论:
- 在GH缺乏症的儿童中,GH疗法会诱导眼睛参数的可测量变化,突出显示GH-IGF-1轴在眼睛发育和生理学中的作用.
- 这些发现强调需要定期对接受GH治疗的儿童进行眼科监测.
- 需要进一步的前性研究来阐明这些生物识别变化的长期视觉后果和临床意义.
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