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Updated: Jan 13, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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CoBRA:使用RNA语言模型预测化合物结合部位

Wonkyeong Jang1, Woong-Hee Shin1,2

  • 1Department of Biomedical Informatics, Korea University College of Medicine, 161 Jeongneung-ro, Seongbuk-gu, Seoul 02708, Republic of Korea.

Briefings in bioinformatics
|January 11, 2026
PubMed
概括

一个新的深度学习工具,RNA的复合结合位预测 (CoBRA),仅使用序列数据就能准确预测RNA与药物相互作用. 这种方法优于基于结构的方法,提供了一种灵活的方式来发现新的RNA向治疗方法.

关键词:
RNA语言模型RNA语言模型RNA小分子结合部位的预测卷积神经网络是一种卷积神经网络.深度学习是一种深度学习.预先训练有素的嵌入方式

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