甜食消费与妊娠前之间的关联:从观察性研究和孟德尔随机化分析中得出的见解
Hua Lin1, Lianqin Zheng2, Xiumin Jiang2
1Obstetrics Department, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou City, Fujian Province, China.
Clinical and experimental hypertension (New York, N.Y. : 1993)
|January 11, 2026
概括
在一项队列研究中,经常摄入甜食与更高的孕前 (PE) 风险有关,但门德尔随机化没有证实因果关系. 较高的体重指数 (BMI) 被确定为PE的因果因素.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 遗传流行病学遗传流行病学
背景情况:
- 孕前 (PE) 是一种严重的妊娠并发症,其不清楚的饮食风险因素.
- 以前的研究表明,甜食消费与代谢障碍之间存在联系,但其在PE中的具体作用尚未得到充分确立.
研究的目的:
- 调查习惯的甜食摄入量与患孕前的风险之间的潜在因果关系.
- 探索身体质量指数 (BMI) 作为潜在的媒介或孕前的独立风险因素的作用.
主要方法:
- 对1146名孕妇进行了回顾性队列研究 (60名患有PE,1086名对照).
- 评估了饮食习惯,包括甜食消费,并使用后勤回归来分析关联.
- 门德尔的随机化 (MR) 分析,利用来自大规模人口数据库的遗传变异,被用来推断因果关系.
主要成果:
- 队列研究发现频繁食用甜食 (≥3次/周) 与增加PE风险 (OR=2.51) 之间存在显著的关联.
- 然而,MR分析没有证据表明甜食摄入对PE的因果关系.
- 在较高的BMI和PE风险增加 (OR=1.56) 之间发现了强烈的因果关系.
结论:
- 虽然观察数据表明甜食摄入量和PE之间存在联系,但孟德尔随机化不支持因果关系.
- 体重指数升高,可能受到总体能量摄入的影响,是孕前的重要因果风险因素.
- 需要进一步的研究来阐明饮食,体重控制和代谢健康在怀孕结果中的复杂相互作用.
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