对肠心轴的比较见解:跨物种和跨种群的观点
Tony W H Tang1, Kiramat Ullah1,2, Jia-Jung Lee3
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Gut microbes
|January 11, 2026
概括
肠道微生物群影响心血管健康,但研究结果因物种和种群而异. 本综述综合了跨物种的数据,以确定保存的肠心轴通路和针对针对性干预的特定环境因素.
科学领域:
- 微生物学 微生物学
- 心血管科学 心血管科学
- 宿主-微生物相互作用
背景情况:
- 肠道微生物群研究显著促进了对心血管疾病的理解.
- 由于物种差异和人口异质性,翻译这些见解是具有挑战性的.
研究的目的:
- 在肠心轴上合成跨物种和跨种群证据.
- 确定心血管健康中宿主微生物相互作用的保存与上下文依赖特征.
- 概述一个基于微生物群的诊断和干预的框架.
主要方法:
- 对动物,猪,非人类灵长类动物和多民族人类队伍当前证据的审查.
- 对肠心轴的保存和上下文依赖特征的分析.
- 整合了机理学研究和临床观察结果的发现.
主要成果:
- 动物模型对于机械学发现至关重要;大型动物模型更好地模仿人类心脏生理学.
- 人类研究显示,在各种心血管疾病中,微生物和代谢物具有不同的特征.
- 保存的功能途径 (例如,SCFA生产,胆酸代谢) 与心血管风险相关,而人口特异性特征 (遗传学,饮食) 增加了复杂性.
结论:
- 了解肠心轴需要整合多样化的证据,承认既保留的途径和特定人口的背景.
- 开发有效的基于微生物群的心血管干预措施需要考虑到生物,文化和环境的多样性.
相关概念视频
Regulation of Heart Rates
3.7K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
3.7K
Anatomy of the Heart
119.0K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
119.0K
Anatomy of the Heart
2.5K
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
2.5K
Overview of the Heart
12.6K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
The heart's structure...
12.6K
Development of the Heart
2.0K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
2.0K


