在肠道感染中人类肠道微生物群:从关联到翻译
Qi Yin1,2, Samriddhi Gupta1, Efrat Muller1
1Department of Veterinary Medicine, University of Cambridge, United Kingdom.
Gut microbes
|January 11, 2026
概括
肠道微生物群影响肠道感染和抗菌素耐药性. 了解这些相互作用是开发肠道健康新诊断和治疗方法的关键.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 肠道感染导致全球显著的发病率,死亡率和经济损失,由抗菌素耐药性加剧.
- 肠道微生物组发挥着双重作用,调解易感性和严重性,但也可能促进感染.
- 机制包括殖民抵抗,资源竞争,免疫调节,交叉养和水平基因转移.
研究的目的:
- 综合关于肠道感染中的微生物组-病原体相互作用的证据.
- 概述改变整个生命周期的疾病风险的因素.
- 评估当前的临床应用,并确定研究缺口.
主要方法:
- 对微生物组与病原体相互作用的相关和机械学证据的审查.
- 对肠道感染风险的宿主,环境和社会经济变化因素的分析.
- 评估现有的临床应用和现场局限性.
主要成果:
- 肠道微生物组显著影响肠道感染的易感性,病原体扩散和疾病严重程度.
- 宿主,环境和社会经济因素调节整个生命的肠道感染风险.
- 目前的临床应用是有限的,仍然存在关键知识差距.
结论:
- 需要进一步的研究来完善微生物组-病原体生态学的因果模型.
- 针对肠道感染的向诊断和治疗需要对这些复杂的相互作用有更深入的了解.
- 解决肠道感染中的抗菌素耐药性需要针对微生物组的战略.
相关概念视频
What is Monogastric Digestion?
74.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
74.9K
Anatomy of the Intestines
86.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.6K
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Translation
17.5K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
Translation Produces the Building Blocks of Life
Proteins are...
17.5K
Translation
155.1K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
155.1K
Physiology of Enteric Nervous System and Gut Health
853
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
853


