没有可行的病变细胞的透皮质活检 - 识别不同的组织学模式可以帮助预测非诊断性与真负面活检,并指导临床管理
Anisha Jacob1, Richard Simon1, Tatjana Antic1
1Department of Pathology, The University of Chicago, Chicago, IL, USA.
Annals of diagnostic pathology
|January 11, 2026
概括
非诊断性质活检 (RMBs) 可能会令人困惑. 这些活检中的特定组织学模式有助于预测恶性瘤,指导更好的患者管理,减少错误诊断.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 透皮质活检 (RMB) 对于诊断和管理质量至关重要.
- 非诊断的RMB发生在10%-21%的病例中,使临床决策复杂化.
研究的目的:
- 为了确定非诊断的RMB中的特定组织学模式是否与临床结果相关.
- 评估这些模式是否可以指导对质的管理决策.
主要方法:
- 在2005年至2024年间,对539个连续的人民币进行了回顾性分析.
- 在64个非诊断活检中组织学模式的分类.
- 使用电子医疗记录对临床结果的评估.
主要成果:
- 在非诊断的RMB中发现了七种不同的组织学模式.
- 在74%的病例中,图案1-4 (良性羊皮膜,慢性变化,亡,肌瘤) 与恶性瘤有关.
- 5-7的模式 (炎症状况,碎片) 仅在12.5%的病例中与恶性瘤有关 (p < 0.000005).
结论:
- 非诊断的RMB中的某些组织学特征可以预测恶性瘤.
- 识别这些模式有助于病理学家从非诊断结果中区分真负结果.
- 这种分类改善了患者的管理,并降低了错过质恶性瘤的风险.
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