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Updated: Jul 3, 2026

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单细胞转录组学表明,母体多二暴露导致雌性小鼠后代肝脏中细胞类型特定的代谢反应失调

Joe Jongpyo Lim1, Youjun Suh2, Xueshu Li3

  • 1Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington; Environmental Health and Microbiome Research Center (EHMBRACE), University of Washington, Seattle, Washington; Institute for Systems Biology, Seattle, Washington.

Drug metabolism and disposition: the biological fate of chemicals
|January 11, 2026
PubMed
概括

母亲接触多双 (PCB) 会改变雌性后代的肝脏发育. 单细胞分析揭示了代谢和免疫功能的细胞特异性干扰,长期影响肝脏健康.

关键词:
发育性暴露 发育性暴露肝脏 肝脏 肝脏 肝脏肝脏生理学 肝脏生理学持久性有机污染物 持久性有机污染物聚化双烯的多种类型一个单细胞RNA-seqq.

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Cell Specific Gene Expression01:58

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...