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Updated: Jan 13, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
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Published on: February 15, 2016

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作为抗结核剂的新一类2-amino-3,4-dihydroquinazolines的结构-活性关系研究

Lena Trifonov1, Helena I Boshoff1, Jose Santinni O Roma1

  • 1Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Bioorganic & medicinal chemistry
|January 11, 2026
PubMed
概括

研究人员发现了一种新型的2-amino-3,4-dihydroquinazoline化合物,有效抗药物敏感和耐药结核病菌株. 尽管有前景的活性和低毒性,但由于平面结构与活性关系以及未确定的作用机制,进一步的优化被停止了.

关键词:
这是一种2-氨基-3,4-二基纳素.它具有抗结核活性.结构与活动的关系.结核病是一种疾病.

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