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Updated: Jan 13, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Published on: November 11, 2016

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通过D-氨基酸修饰的μ-CnIIICIC抑制人类Nav1.4

Renfei Wu1, Zhuying Wang2, Yuan Quan3

  • 1Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, China; PeptiOrigin Biotechnology Co., Ltd., Shenzhen 518000, China.

Bioorganic chemistry
|January 11, 2026
PubMed
概括

在抑制剂μ-CnIIIC中的D-氨基酸替代显著增强了电压导入通道NaV1.4.4的抑制. 这种修改提高了稳定性和结合亲和力,为神经肌肉疾病治疗提供了一个有前途的策略.

关键词:
D-氨基酸的修饰方法hNa(V) 1.4 在V) 1.4 中.这就是M-CnIIICIC.

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