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Updated: Jan 13, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

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TLR3刺激会使衰老的介质细胞干细胞复苏,并恢复移植对宿主疾病中的免疫抑制功能

Linlin Jin1, Ziqi Hu1, Yuxin Huang1

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China; Tianjin Institutes of Health Science, Tianjin, China.

Transplant immunology
|January 11, 2026
PubMed
概括

细胞衰老降低了介质干细胞 (MSC) 治疗移植对宿主疾病 (GVHD) 的有效性. 激活托尔类受体3 (TLR3) 与多I:C一起,可以使老年MSC复苏,恢复其治疗潜力.

关键词:
陈旧的MSC已经老了在GVHD中,GVHD是什么?免疫抑制功能 免疫抑制功能单细胞转录组学 单细胞转录组学在TLR3中,它是TLR3.

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