两个欧洲国家的与感染有关的儿童死亡率,2015 - 2023年:中断时间序列分析
Manon Jaboyedoff1, Pierre Alex Crisinel2, Zaba Valtuille3
1Unit of Pediatric Infectious Diseases and Vaccinology, Service of Pediatrics, Department Women-Mother-Child, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 50, 1011 Lausanne, Switzerland; Paris Cité University, INSERM UMR 1137, Infection, Antimicrobials, Modelling, Evolution (IAME), 16 rue Henri Huchard, 75018 Paris, France.
非药物干预 (NPI) 减少了16%的儿童感染死亡. 这突显了针对性战略的潜力,以降低超越流行病背景的可预防儿科死亡率.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 儿科 儿科 儿科
背景情况:
- 感染是全球儿童死亡的主要原因之一.
- 在COVID-19大流行期间,非药物干预 (NPI) 影响了传染病的传播.
- 这些NPI对儿科感染相关死亡率的影响需要评估.
研究的目的:
- 评估NPI对儿科感染相关死亡率的影响.
- 量化与NPI实施和随后时期相关的死亡率变化.
- 确定持续减少儿童感染死亡的潜力.
主要方法:
- 基于人口的中断时间序列分析 (2015-2023) 使用法国和瑞士的国家数据.
- 对18岁以下个体每月感染相关死亡率的分析.
- 在NPI前,NPI后和NPI后的出生队列之间比较死亡率比率 (MRR).
主要成果:
- 在32,619例儿科死亡中,共发生了8272例感染相关死亡.
- 在NPI期间,与感染相关的死亡率下降了16% (95%CI:-23%至-7%).
- 这种减少估计减少了221例死亡 (95% CI:90至371).
- 2019年和2020年的出生队列与NPI前队列相比,与感染相关的MRR显著较低 (MRR=0.80).
结论:
- 在NPI期间观察到的儿童感染死亡率的减少是显著的.
- 这一发现强调了可预防的儿童死亡率的巨大负担.
- 有针对性的预防策略可以在流行病环境之外,可持续地减少与感染有关的死亡.
更多相关视频
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
06:11Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip
Published on: March 29, 2024
相关概念视频
Steps in Outbreak Investigation
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
