抑制性控制相关的神经通路的早期逆境,以内化问题在青春期前的青春期
Krupali R Patel1, Brianna N Hernandez1, Alyssa J Parker2
1Department of Psychology, San Diego State University, San Diego, California, United States.
Journal of affective disorders
|January 11, 2026
概括
早期的生活压力可能导致青少年精神病理,但前带皮层 (ACC) 等大脑区域的神经活动可能会提供保护. 特定的大脑反应可以减轻早期逆境对心理健康的影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 早期的生活逆境 (例如,威胁,剥夺) 对青少年的心理健康有持久的影响.
- 心理病理发展的个体差异表明有保护性神经机制.
- 神经通路可能会在早期生活压力后的结果中产生差异.
研究的目的:
- 研究早期逆境和青少年内化症状之间的纵向关系.
- 为了检查特定大脑区域的神经功能是否能缓和这种关系.
- 了解威胁与剥夺暴露如何通过神经活动影响内化症状.
主要方法:
- 利用了ABCD®研究中的神经成像数据 (N=4881).
- 检查了前带带皮质 (ACC),上额头 (SFG) 和下额头 (IFG) 中与抑制控制相关的神经功能.
- 评估了早期逆境 (威胁/剥夺) 与一年后内化症状之间的联系的适度.
主要成果:
- 累积的威胁/剥夺暴露与内化症状正相关.
- 在抑制过程中高ACC和左SFG激活减弱了威胁-不利关系.
- 左上方的SFG激活放大了贫困与逆境的联系;IFG没有显示任何影响.
结论:
- 神经功能在调解早期生活逆境的影响方面发挥着差异性作用.
- 大脑区域和逆境类型的相互作用对于理解精神病理发展至关重要.
- 对神经通路的进一步研究是必要的,以基于大脑的方法来早期的生命干预.
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