瘤学中的微生物组调节免疫疗法:当前应用和未来前景
Xi Yang1, Yu Liu2, Keyan Miao2
1College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China.
Seminars in cancer biology
|January 11, 2026
概括
肠道微生物群影响癌症免疫疗法的有效性和副作用. 准这些微生物有望改善癌症治疗结果,但仍然存在挑战.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 癌症免疫疗法已经彻底改变了癌症治疗,但面临着响应变化和抵抗的挑战.
- 瘤微环境,包括其微生物组成,显著影响免疫疗法疗效和免疫相关不良事件 (irAEs).
研究的目的:
- 探索微生物群在调节抗瘤免疫力和影响癌症免疫治疗结果中的作用.
- 审查当前和新兴的基于微生物组的战略,以加强癌症免疫疗法和管理irAEs.
主要方法:
- 关于宿主微生物组与癌症免疫治疗之间的相互作用的当前科学文献的综述.
- 分析微生物群落调节瘤免疫微环境的机制.
- 对瘤学的微生物向干预措施的临床前和临床数据的检查.
主要成果:
- 微生物群通过各种机制影响抗瘤免疫力,包括微生物代谢物和分子模式.
- 基于微生物组的策略,如益生菌和便微生物群移植,在早期临床研究中显示出改善免疫治疗反应和减少irAEs的潜力.
- 重要的挑战包括菌株特异性,个体间的变异性,以及确保微生物组干预措施的安全性.
结论:
- 肠道微生物组是癌症免疫疗法反应和毒性的关键因素.
- 针对微生物组为个性化癌症治疗提供了一个有希望的途径,但需要进一步理解机制和标准化方法.
- 未来的研究应该专注于整合多学科数据和开发个性化干预措施,以优化微生物组调节用于精密免疫疗法.
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