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奇州迪黄药在与年龄相关的干眼疾病中调节补充系统:通过临床-奥米克-动物集成进行三方验证
Lihao Chen1, Jun Peng2, Genyan Qin3
1Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Journal of ethnopharmacology
|January 11, 2026
概括
齐祖迪黄药 (QJDHW) 通过调节补体系统,有效治疗与年龄相关的干眼疾病 (DED). 这种传统的中医药可以减少炎症,改善眼睛表面的健康状况,提供一种新的治疗方法.
科学领域:
- 综合医学是一个整体的医学.
- 眼科医生 眼科 眼科
- 蛋白质组学是指蛋白质组学.
背景情况:
- 与年龄相关的干眼疾病 (DED) 涉及眼膜不稳定性和眼表面失生症,目前的治疗方法缺乏持续的疗效.
- 传统中医 (TCM) 为与年龄相关的DED提供了多目标干预措施,但Qiju Dihuang Pill (QJDHW) 的分子机制需要阐明.
研究的目的:
- 为了研究与年龄相关的DED的蛋白质组概况.
- 探索QJDHW在治疗与年龄相关的DED中的特定机制.
主要方法:
- 在30名参与者 (15个与年龄相关的DED,15个对照组) 中进行了综合临床表型,omics分析和草药干预.
- 使用数据独立获取 (DIA) 的血清蛋白质组分析.
- 建立了一个与年龄相关的DED大鼠模型,以评估QJDHW对眼睛表面,认知功能和分子标记物的影响 (补充调节者C3,C5,CFHR3,CD59;炎症标记者IL-6).
主要成果:
- 蛋白质组分析确定了丰富的补充和凝血级联通路,其中包括C5,CD59和CFHR3.3等差异性蛋白质.
- 高剂量的QJDHW显著改善了液分泌,膜稳定性和眼睛表面形态.
- QJDHW上调的补充抑制剂 (CFHR3,CD59) 和下调的补充激活剂 (C3,C5) 和IL-6.
结论:
- QJDHW通过调节补体激活抑制系统和抑制C3/C5介导的炎症来治疗与年龄相关的DED.
- 这项研究为TCM在治疗与年龄相关的眼部疾病方面的整体方法提供了分子证据.
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