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通过系统调制G-三合体•G接口连接的工程互锁G线组件

Yanwei Cao¹, Yongjun Zhong², Yusi Yan²

¹Institute of Pharmaceuticals, School of Pharmaceutical Sciences, Taizhou University, Taizhou, 318000, Zhejiang Province, China; Jiangsu Key Laboratory of Organoid Engineering and Precision Medicine, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.

International journal of biological macromolecules

|January 11, 2026

概括

在G-quadruplex (G4) 序列中长的关氨酸片段的位置决定了相互锁定的G4架构的组装. 特定的G-tract放置和离子条件影响G4-线堆叠和光发射,使合理的纳米结构设计成为可能.

科学领域:

超分子化学超分子化学
生物物理化学生物物理化学
纳米技术纳米技术

背景情况:

G-四重复 (G4) 结构是由富含关氨酸的序列形成的,在纳米技术中具有潜在的应用.
复杂的G4架构的组装,如互锁的G4线,受序列组成和G-tract特征的影响.
了解G-tract位置的作用对于控制基于G4的纳米结构的形成和特性至关重要.

研究的目的:

系统地研究长G-tract在异质G-tract序列中的位置如何影响互锁G-quadruplex (G4) 架构的组装.
阐明G-tract特征,组装途径,以及由此产生的G4纳米结构的光物理性质之间的关系.
确定提高产量和控制互锁G4电线组装的策略.

主要方法:

使用不同长度的G-tract位置的异质G-tract序列对G-quadruplex组件的系统研究.
分析G4架构的形成,包括端堆叠模式 (5'-5'与5'-3') 和接口堆叠 (5环与5/6环).
使用光光谱学对G4结构进行表征,以确定与不同组装路径相关的辐射波长.
评估N-cyanoimidazole驱动的末结合,以提高G4线的产量.

主要成果:

组装成互锁的G4二元体 (5'-5'堆叠) 仅在具有5'终端长G通道和3'终端胆氨基基的序列中观察到.
大多数其他序列通过5'-3'末端堆叠形成相互锁定的G4线,其组装路径取决于G-tract在形成分子内G-tetrads中的作用.
路径I (5环接口) 产生了330nm的辐射,而路径II (5/6环接口) 产生了385nm的辐射;中心G-tracts显示了路径可塑性.
由N-cyanoimidazole驱动的末端绑定显著提高了互锁G4线的产量.

结论:

长G-tract的位置是组装路径和由此产生的互锁G4结构架构的关键决定因素.
特定的G-tract配置和离子环境可以引导形成独特的G4-线堆叠模式和光特性.
这项研究为基于G4的纳米结构的合理设计,调节和优化提供了宝贵的见解和实用方法.

关键词:

组装路径的组装路径.化学结合法化学结合法这就是G-四重复式.接口堆叠方式接口堆叠互锁的G线电线.

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