杜申肌力发育不良症中的膀功能障碍:一个叙述性回顾
R R Kikkert1, J M Fock2, G J F J Bos3
1Department of Urology, University Medical Centre Groningen, the Netherlands.
Journal of pediatric urology
|January 11, 2026
概括
杜申肌肉发育不良 (DMD) 经常导致尿路和肠道问题. 这份综述强调了下泌尿道症状 (LUTS) 和排便问题的高率,敦促多学科的护理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 神经学 神经学
- 儿科 儿科 儿科
背景情况:
- 杜琴肌力发育不良 (DMD) 是一种严重的,渐进的骨肌疾病.
- 在DMD的泌尿学并发症包括detrusor过度活跃,膀的低收缩性,尿失禁,detrusor-sphincter不协同作用,和尿病.
- 本综述侧重于DMD患者的膀功能障碍管理.
研究的目的:
- 调查患有DMD的儿童下尿路症状 (LUTS),排便问题,尿路感染 (UTI) 和尿病的发生率.
- 评估泌尿问题对患有DMD的儿童生活质量的影响.
- 为DMD中膀功能障碍管理提供建议.
主要方法:
- 在PubMed,Scopus,Embase,Cochrane和Web of Science进行了全面的文献搜索.
- 根据PRISMA指导方针选择了9项非随机化研究,并使用PICO框架进行分析.
- 通过MINORS标准验证了研究质量.
主要成果:
- 在DMD患者中,LUTS的患病率在32%到85%之间,犹,紧迫性,失禁和频率是最常见的.
- 在32%到70%的患者中报告了同时出现的排便问题.
- 关于尿路感染,尿病,生活质量和治疗结果的信息很少.
结论:
- 脑膜炎症与尿道并发症的高患病率有关,特别是LUTS和排便问题.
- 关于尿路感染,尿病,生活质量和DMD治疗疗效的数据显著缺乏.
- 建议包括儿科泌尿科医生在内的多学科管理来解决DMD中的LUTS和肠道功能障碍.
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